1. Plasma Cell Myeloma
Usually osteolytic. Osteosclerotic lesions are associated with peripheral neuropathy (POEMS syndrome).
Russel bodies are extracellular globules of polymerized immunoglobulines.
Mott cells have characteristic vacuoles.
CD38 is distinct antigen. CD138 is reliable marker for differentiating normal and neoplastic plasma cells.

Diagnostic criteria of solitary myeloma.
> A single tumour in the bone marrow.
> Solitary osteolytic lesion.
> Absence of other lesions on whole bone survey.
> No evidence of plasmacytosis in the bone marrow.

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